Destroy All Humans! is a remake of the 2005 action-adventure game. The player is Crypto-137, a Furon alien sent to 1950s America to harvest human DNA while working against the US government.
Players use psychic powers such as telekinesis and mind control, alien weapons and a flying saucer to attack towns and military bases, and Crypto can disguise himself as a human to move around unnoticed. The remake has rebuilt visuals and adds the restored mission Lost Mission of Area 42.
The Nintendo Switch 2 version has enhanced visuals, denser environments and output up to 1440p, and includes the Skin Pack DLC.